Evaluation of the trabecular bone score in 35 children and adults with X-linked hypophosphatemic rickets
JOURNAL OF BONE AND MINERAL METABOLISM(2023)
摘要
Introduction The aim of this study is to evaluate and compare the trabecular bone scores (TBSs) of 11 children and 24 adults with X-linked hypophosphatemic rickets (XLH) and non-XLH subjects from a tertiary center. Materials and methods The areal bone mineral density at the lumbar spine (LS-aBMD) and LS-aBMD Z score were analyzed by dual-energy X-ray absorptiometry. The bone mineral apparent density (BMAD) and LS-aBMD Z score adjusted for height Z score (LS-aBMD–HAZ) were calculated. The TBS was determined using TBS iNsight software based on DXA images from the Hologic QDR 4500 device. Results The XLH patients exhibited a higher mean LS-aBMD Z score, BMAD, and TBS than the non-XLH subjects ( p < 0.01). LS-aBMD–HAZ and BMAD were greater in the XLH children than those in their corresponding non-XLH subjects ( p < 0.01 and p = 0.02), and the XLH children trended toward a greater TBS ( p = 0.06). The XLH adults had a higher LS-aBMD Z score, BMAD, and TBS than the non-XLH subjects ( p < 0.01). When stratified by metabolic status according to the serum values of bone formation markers, compensated adult patients had a higher LS-aBMD Z score, BMAD, and TBS than non-XLH subjects ( p < 0.01). Noncompensated patients had higher LS-aBMD Z scores and BMAD results than non-XLH subjects. However, TBS values did not differ statistically significantly between those groups ( p = 0.45). Conclusion The higher LS-aBMD Z score, BMAD, and TBS result in the XLH patients compared to non-XLH subjects indicates an increased amount of trabecular bone within the lumbar spine, regardless of extraskeletal calcifications.
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关键词
Trabecular bone score,Bone mineral density,DXA,X-linked hypophosphatemic rickets
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