Biomarkers of aging

Hainan Bao,Jiani Cao,Mengting Chen,Min Chen,Wei Chen,Xiao Chen,Yanhao Chen,Yu Chen,Yutian Chen,Zhiyang Chen,Jagadish K. Chhetri,Yingjie Ding,Junlin Feng, Jun Guo,Mengmeng Guo,Chuting He,Yujuan Jia,Haiping Jiang,Ying Jing,Dingfeng Li,Jiaming Li,Jingyi Li,Qinhao Liang,Rui Liang,Feng Liu,Xiaoqian Liu,Zuojun Liu,Oscar Junhong Luo,Jianwei Lv,Jingyi Ma, Kehang Mao,Jiawei Nie,Xinhua Qiao,Xinpei Sun,Xiaoqiang Tang,Jianfang Wang,Qiaoran Wang,Siyuan Wang,Xuan Wang,Yaning Wang,Yuhan Wang, Rimo Wu,Kai Xia,Fu-Hui Xiao,Lingyan Xu,Yingying Xu,Haoteng Yan,Liang Yang,Ruici Yang,Yuanxin Yang,Yilin Ying,Le Zhang,Weiwei Zhang,Wenwan Zhang,Xing Zhang,Zhuo Zhang, Min Zhou,Rui Zhou,Qingchen Zhu,Zhengmao Zhu,Feng Cao,Zhongwei Cao,Piu Chan,Chang Chen,Guobing Chen,Hou-Zao Chen,Jun Chen,Weimin Ci,Bi-Sen Ding,Qiurong Ding,Feng Gao,Jing-Dong J. Han,Kai Huang,Zhenyu Ju,Qing-Peng Kong,Ji Li,Jian Li,Xin Li,Baohua Liu,Feng Liu,Lin Liu,Qiang Liu,Qiang Liu,Xingguo Liu,Yong Liu,Xianghang Luo,Shuai Ma,Xinran Ma,Zhiyong Mao,Jing Nie,Yaojin Peng,Jing Qu,Jie Ren,Ruibao Ren,Moshi Song,Zhou Songyang,Yi Eve Sun,Yu Sun,Mei Tian,Shusen Wang,Si Wang,Xia Wang,Xiaoning Wang,Yan-Jiang Wang,Yunfang Wang,Catherine C. L. Wong,Andy Peng Xiang,Yichuan Xiao,Zhengwei Xie,Daichao Xu,Jing Ye,Rui Yue,Cuntai Zhang,Hongbo Zhang,Liang Zhang,Weiqi Zhang,Yong Zhang,Yun-Wu Zhang,Zhuohua Zhang,Tongbiao Zhao,Yuzheng Zhao,Dahai Zhu,Weiguo Zou,Gang Pei,Guang-Hui Liu

SCIENCE CHINA-LIFE SCIENCES（2023）

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摘要

Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant.

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关键词

aging, senescence, biomarker, clock

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