Law of precise matching and assembly chromosomes: A hypothesis for chromosome theory of inheritance and its implications in medical genetics

It is well known that chromosome abnormalities are closely related to many diseases or disorders and devel-opmental abnormalities. However, our understanding of chromosome abnormalities and their roles in diseases or disorders and embryonic development is limited. Here, we propose a hypothesis for the chromosome theory of inheritance, and for the study of medical genetics, human embryology, and reproductive medicine. Our hy-pothesis is the law of precise matching and assembly chromosomes, which means that in a fertilized egg, via centromeres, haploid chromosomes with the same identity number but nonhomologous from two parents are precisely united and assembled into a complete set of diploid chromosomes. We believe that our hypothesis offers valuable insights into the study of genetics, reproduction and development, and medicine; which can be further explored and reflected upon: (1) it will help to elucidate the process and underlying molecular mechanisms and signal pathways of precise matching and assembly chromosomes, and the molecular biological underlying of chromosome abnormalities; (2) it will be helpful to discover the causes of chromosomal abnormalities and its related diseases; (3) it will be helpful to settle the issues of birth defects, spontaneous abortions, and infertility in human beings; (4) it will help to promote the revision of genetic and medical textbooks, and help train a new generation of genetic and medical talents for the benefits of all species (including human beings themselves); (5) it will help to reveal the origin, survival, reproduction, inheritance and evolution of species. Thus, our hypothesis is worthy of in-depth and extensive study and discussion in the future.