Palladium-catalyzed Sonogashira coupling to synthesis of gem-difluoroenynes

Herein, we developed the palladium-catalyzed Sonogashira-type cross-coupling of 1-bromo-2,2-difluoroethylene with a variety of aromatic and aliphatic terminal alkynes proceeds smoothly at mild reaction condition to access the corresponding gem-difluoroenyne derivatives. 1-Bromo-2,2-difluoroethylene is a useful difluoroethenyl source because of its commercially available and easy-to-handle. This new synthetic protocol provided a novel strategy to directly construct gem-difluoroenynes with good functional group tolerance and high yields.