Development of m-pDS Model for Predicting Solubility of Solid Solutes in Supercritical Carbon Dioxide with a Single Modifier Addition Systems

At present, a model has been developed for predicting solubility of solid solutes in supercritical carbon dioxide with a single modifier addition systems. First, we accumulated a total of 960 solubility data sets for 24 organic solutes using ethanol, methanol, acetone, and ethyl acetate as a modifier, and then developed a solubility correlation model. In the development thereof, a Dimensionless Solubility (pDS) model (Ota et al., 2018), which is a solubility estimation model of a solid solute in a supercritical carbon dioxide pure solvent constructed by the authors previously, was adopted as the basic part, and the solubility promoting effect of the modifier addition systems was newly formulated as an m-pDS model (pDS for a single modifier addition systems) using the Hansen solubility parameter for expressing solute -modi-fier interactions.