Healing of chronic venous ulcers induced with a hydrogel of aloe vera, sorbitol, allantoin and glycerol

Objective: To evaluate the efficacy of a hydrogel composed of aloe vera, sorbitol, allantoin and glycerol, and to study clinically the levels of interleukin 6 (IL-6) for the treatment of venous ulcers (UV). Methods: A single-arm non-randomized clinical trial was conducted in 10 subjects. Each subject was treated with the hydrogel for eight weeks. After completion of the follow-up period, a final assessment of each patient's clinical and molecular scores was performed and compared to baseline data. Results: Patients treated with the hydrogel had a mean UV area reduction of -1.12 cm5 (+/- 2.53), mean volume reduction of -1.47 cm6 (+/- 3.43) and mean perilesional IL-6 value of -1.81 pg/mL (+/- 8.07). Also, a mean reduction in venous clinical severity score (VCSSr) of -9.3 (+/- 2.62) and visual analog scale (VAS) pain score of -5.5 (+/- 2.22) was found. Conclusion: IL-6 is a useful molecular indicator for monitoring wound healing. Treatment with a hydrogel based on aloe vera, sorbitol and allantoin promotes wound healing, improves quality of life and reduces UV pain levels.Conflict of interest: The main researcher, Dr Jorge Ulloa, declares receipt of resources for research by Humany Care. This project was funded by Humany Care.