Discovery of MK-8768, a Potent and Selective Mglur2 Negative Allosteric Modulator.
Michael T. Rudd,Peter J. Manley,Barbara Hanney,Zhaoyang Meng,Youheng Shu,Pablo de Leon, Jessica L. Frie,Yongxin Han,Jenny Miu-Chun Wai,Zhi-Qiang Yang,James J. Perkins,Danielle M. Hurzy,Jesse J. Manikowski,Hong Zhu,Christopher J. Bungard,Antonella Converso,Robert S. Meissner,Mali L. Cosden, Ikuo Hayashi,Lei Ma,Julie O'Brien,Victor N. Uebele,Joel B. Schachter,Neetesh Bhandari, Gwendolyn J. Ward,Kerry L. Fillgrove,Bing Lu,Yuexia Liang,David C. Dubost,Vanita Puri,Donnie M. Eddins,Joshua D. Vardigan,Robert E. Drolet,Jonathan T. Kern,Jason M. Uslaner ACS Medicinal Chemistry Letters（2023）
Key words
mGluR2,glutamate,Ames,cognition
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