A randomized non-inferiority study evaluating the efficacy of 2 commercially available teat sealants in dairy cows

The primary objective of this study was to compare the effi­cacy of a new internal teat sealant (ShutOutTM, Merck Animal Health, Madison, NJ) (SO) to the current U.S. industry leader (Orbeseal®, Zoetis, Parsippany, NJ) (ORB). This comparison was based on a non-inferiority evaluation of quarter-level new in­fection risk during the dry period, with secondary comparisons of cure risk, incidence of clinical mastitis at the cow level dur­ing the first 120 days in milk, as well as cow-level performance in early lactation based on milk production, somatic cell count (SCC), and risk for removal from the herd.