Long COVID-19 Cardiac Complications Are Associated With Autoimmunity to Cardiac Self-Antigens Sufficient to Cause Cardiac Dysfunction.

HomeCirculationVol. 148, No. 6Long COVID-19 Cardiac Complications Are Associated With Autoimmunity to Cardiac Self-Antigens Sufficient to Cause Cardiac Dysfunction No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextLong COVID-19 Cardiac Complications Are Associated With Autoimmunity to Cardiac Self-Antigens Sufficient to Cause Cardiac Dysfunction Marco Cremonesi, Arianna Felicetta, Francesco Cannata, Simone Serio, Jasper J.P. van Beek, Sara Bombace, Ilaria My, Veronica Zanon, Chiara Catalano, Vasiliki Papadopoulou, Lorenzo Monti, Mauro Chiarito, Giulio Stefanini, Cristina Panico, Marco Francone, Enrico Lugli, Marinos Kallikourdis and Gianluigi Condorelli Marco CremonesiMarco Cremonesi Adaptive Immunity Laboratory (M. Cremonesi, C.C., V.P., M.K.), Rozzano, Milan, Italy. *M. Cremonesi and A. Felicetta contributed equally. Search for more papers by this author , Arianna FelicettaArianna Felicetta Cardio Center (A.F., F.C., S.S., S.B., I.M., M. Chiarito, G.S., C.P., G.C.), Rozzano, Milan, Italy. *M. Cremonesi and A. Felicetta contributed equally. Search for more papers by this author , Francesco CannataFrancesco Cannata https://orcid.org/0000-0002-5842-5293 Cardio Center (A.F., F.C., S.S., S.B., I.M., M. Chiarito, G.S., C.P., G.C.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). †F. Cannata, S. Serio, J.J.P. van Beek, S. Bombace, and I. My contributed equally. Search for more papers by this author , Simone SerioSimone Serio https://orcid.org/0000-0002-7294-2094 Cardio Center (A.F., F.C., S.S., S.B., I.M., M. Chiarito, G.S., C.P., G.C.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). †F. Cannata, S. Serio, J.J.P. van Beek, S. Bombace, and I. My contributed equally. Search for more papers by this author , Jasper J.P. van BeekJasper J.P. van Beek https://orcid.org/0000-0001-5888-0125 Laboratory of Translational Immunology (J.J.P.v.B., V.Z., E.L.), Rozzano, Milan, Italy. †F. Cannata, S. Serio, J.J.P. van Beek, S. Bombace, and I. My contributed equally. Search for more papers by this author , Sara BombaceSara Bombace https://orcid.org/0000-0002-7716-9635 Cardio Center (A.F., F.C., S.S., S.B., I.M., M. Chiarito, G.S., C.P., G.C.), Rozzano, Milan, Italy. †F. Cannata, S. Serio, J.J.P. van Beek, S. Bombace, and I. My contributed equally. Search for more papers by this author , Ilaria MyIlaria My https://orcid.org/0000-0002-1676-4633 Cardio Center (A.F., F.C., S.S., S.B., I.M., M. Chiarito, G.S., C.P., G.C.), Rozzano, Milan, Italy. †F. Cannata, S. Serio, J.J.P. van Beek, S. Bombace, and I. My contributed equally. Search for more papers by this author , Veronica ZanonVeronica Zanon Laboratory of Translational Immunology (J.J.P.v.B., V.Z., E.L.), Rozzano, Milan, Italy. Search for more papers by this author , Chiara CatalanoChiara Catalano https://orcid.org/0000-0002-9999-6404 Adaptive Immunity Laboratory (M. Cremonesi, C.C., V.P., M.K.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). Search for more papers by this author , Vasiliki PapadopoulouVasiliki Papadopoulou Adaptive Immunity Laboratory (M. Cremonesi, C.C., V.P., M.K.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). Search for more papers by this author , Lorenzo MontiLorenzo Monti https://orcid.org/0000-0001-6656-3568 Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital (L.M., M.F.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). Search for more papers by this author , Mauro ChiaritoMauro Chiarito https://orcid.org/0000-0002-9333-2658 Cardio Center (A.F., F.C., S.S., S.B., I.M., M. Chiarito, G.S., C.P., G.C.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). Search for more papers by this author , Giulio StefaniniGiulio Stefanini https://orcid.org/0000-0002-3558-6967 Cardio Center (A.F., F.C., S.S., S.B., I.M., M. Chiarito, G.S., C.P., G.C.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). Search for more papers by this author , Cristina PanicoCristina Panico Cardio Center (A.F., F.C., S.S., S.B., I.M., M. Chiarito, G.S., C.P., G.C.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). Search for more papers by this author , Marco FranconeMarco Francone Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital (L.M., M.F.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). Search for more papers by this author , Enrico LugliEnrico Lugli Laboratory of Translational Immunology (J.J.P.v.B., V.Z., E.L.), Rozzano, Milan, Italy. Search for more papers by this author , Marinos KallikourdisMarinos Kallikourdis Correspondence to: Marinos Kallikourdis, PhD, Via Manzoni 56, Rozzano 20089, Milan, Italy, Email E-mail Address: [email protected] https://orcid.org/0000-0001-9318-3368 Adaptive Immunity Laboratory (M. Cremonesi, C.C., V.P., M.K.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). ‡M. Kallikourdis and G. Condorelli contributed equally. Search for more papers by this author and Gianluigi CondorelliGianluigi Condorelli Gianluigi Condorelli, MD, PhD, Via Manzoni 56, Rozzano 20089, Milan, Italy, Email E-mail Address: [email protected] https://orcid.org/0000-0003-0481-6843 Cardio Center (A.F., F.C., S.S., S.B., I.M., M. Chiarito, G.S., C.P., G.C.), Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (F.C., S.S., C.C., V.P., L.M., M. Chiarito, G.S., C.P., M.F., M.K., G.C.). ‡M. Kallikourdis and G. Condorelli contributed equally. Search for more papers by this author Originally published7 Aug 2023https://doi.org/10.1161/CIRCULATIONAHA.122.062672Circulation. 2023;148:504–507Footnotes*M. Cremonesi and A. Felicetta contributed equally.†F. Cannata, S. Serio, J.J.P. van Beek, S. Bombace, and I. My contributed equally.‡M. Kallikourdis and G. Condorelli contributed equally.For Sources of Funding and Disclosures, see page 507.Circulation is available at www.ahajournals.org/journal/circ.Correspondence to: Marinos Kallikourdis, PhD, Via Manzoni 56, Rozzano 20089, Milan, Italy, Email marinos.kallikourdis@humanitasresearch.itGianluigi Condorelli, MD, PhD, Via Manzoni 56, Rozzano 20089, Milan, Italy, Email gianluigi.condorelli@hunimed.euREFERENCES1. 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