Dupilumab-induced eosinophilia in patients with diffuse type 2 chronic rhinosinusitis.

Fabio S Ryser, Ayla Yalamanoglu,Alan Valaperti,Catrin Brühlmann, Tina Mauthe,Stephan Traidl,Michael B Soyka,Urs C Steiner

Allergy（2023）

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摘要

Our findings suggest that increased eosinophils in type 2 CRS are associated with a good clinical response to dupilumab. Patients with elevated IL-4 at baseline developed dupilumab-induced transient eosinophilia. We identified the downregulation of VCAM-1 and surface markers CD49d and CXCR4 on eosinophils as possible explanations of dupilumab-induced eosinophilia.

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关键词

chronic rhinosinusitis,eosinophilia

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