Renal arterial infusion of tempol prevents medullary hypoperfusion, hypoxia, and acute kidney injury in ovine Gram-negative sepsis.

Ashenafi H Betrie,Shuai Ma,Connie P C Ow,Rachel M Peiris,Roger G Evans,Scott Ayton,Darius J R Lane,Adam Southon,Simon R Bailey,Rinaldo Bellomo,Clive N May,Yugeesh R Lankadeva

Acta physiologica (Oxford, England)（2023）

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摘要

In ovine Gram-negative sepsis, renal arterial infusion of tempol prevented renal medullary hypoperfusion and hypoxia and AKI and decreased TNF-α expression and uncoupling of eNOS. However, it did not affect markers of oxidative/nitrosative stress, which were significantly decreased by Gram-negative sepsis.

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medullary hypoperfusion,sepsis,renal arterial infusion,acute kidney injury,tempol

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