Commentary on: Safety and feasibility of percutaneous needle tunneling with platelet-rich plasma injections for Peyronie’s disease in the outpatient setting: a pilot study

The objective of this study is to evaluate the safety and feasibility of the combined simultaneous percutaneous needle tunneling coupled with injection of platelet-rich plasma in the outpatient department for the treatment of Peyronie’s disease. This prospective, non-randomized, cohort and preliminary study included patients who underwent this procedure from November 2020 to July 2022. The main outcome was an improvement in penile curvature. Fifty-four patients were enrolled and underwent 6 sessions under local anesthesia followed by vacuum therapy for the treatment of Peyronie’s disease in our outpatient unit. The amendment of the curvature angle was significant with a median correction percentage of −44.40% interquartile range (−66.70 to (−39.70)), [ p -value = 0.001, 95% CI (−29.76 to (−18.02)), paired Student’s t -test]. The median pre-treatment curvature angle was 45° (40–75), and the median post-treatment was 30° (20–40). The median score for pain during the procedure was 3 (0–4.25) according to a 10-point visual analogic scale. After two hours, 20.37% of patients still had pain but none required any pain medication. 50% of patients had a minor hematoma and 75.93% patients reported penile ecchymosis. A single patient reported an injection site skin infection. In our experience percutaneous needle tunneling with platelet-rich plasma injections for Peyronie’s disease in the outpatient setting is a safe, effective, and feasible treatment of penile deformity for PD.