RBPJ deficiency sensitizes pancreatic acinar cells to KRAS-mediated pancreatic intraepithelial neoplasia initiation.

Leiling Pan,Medhanie A Mulaw,Johann Gout, Min Guo,Hina Zarrin, Peggy Schwarz,Bernd Baumann,Thomas Seufferlein,Martin Wagner,Franz Oswald

Cellular and molecular gastroenterology and hepatology（2023）

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摘要

Our findings imply that downregulation of RBPJ in PDAC patients derepresses Notch targets and promotes KRAS-mediated pancreatic acinar cells transformation and desmoplasia development.

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关键词

Acinar Cells, ADM, PDAC

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