Interpretable AI-assisted clinical decision making (CDM) for dose prescription in radiosurgery of brain metastases

•develop interpretable AI to solely follow the thought process of physicians to effectively model their clinical decision-making (CDM).•This is the first time an interpretable AI model has been developed to use both image and non-image information to predict dose prescription in CDM of radiotherapy.•The models trained based on the actual treatment records showed high prediction accuracy while providing an interpretation of the decision process.•Class activation scores are designed and calculated for the model to illustrate the roles and importance of different inputs in the decision-making process, which was validated by the physician’s interpretation of the decision process.