Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [18F]UCB-H PET imaging

Letizia Vogler, Anna Ballweg, Bernd Bohr,Nils Briel,Karin Wind,Melissa Antons,Lea H. Kunze,Johannes Gnörich,Simon Lindner,Franz-Josef Gildehaus,Karlheinz Baumann,Peter Bartenstein,Guido Boening,Sibylle I. Ziegler,Johannes Levin,Andreas Zwergal,Günter U. Höglinger,Jochen Herms,Matthias Brendel

NeuroImage. Clinical（2023）

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摘要

•[18F]UCB-H was evaluated as a preclinical biomarker of synapse density in Alzheimer’s disease (AD) models.•Decreased PET signals reflected synapse loss in transgenic mice with tau and Aβ pathology.•Multitracer comparison showed that [18F]FDG but not [18F]UCB-H PET is affected by glial metabolism.•Synaptic density may be a more reliable surrogate of neurodegeneration than glucose metabolism in AD models.

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关键词

synaptic loss,tau pathology,mouse models,imaging

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