A series of 7 cases of patients with narcolepsy with hypocretin deficiency without HLA DQB1*06:02 allele.

Silvia Miano,Lucie Barateau, Marco De Pieri,Silvia Riccardi,Celine Thevenin,Mauro Manconi,Yves Dauvilliers

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine（2023）

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摘要

Although rare, this series of 7 cases confirms that hypocretin-deficient narcolepsy should not be excluded in the absence of HLA DQB1*06:02, especially if they are carriers of other high-risk HLA-DQB1 alleles (DQB1*03:01, *03:02, *02:01). These data support the hypothesis that NT1 is a wider disease spectrum linked to the loss of hypocretin peptide.

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