Flk1 Deficiency and Hypoxia Synergistically Promote Endothelial Dysfunction, Vascular Remodeling, and Pulmonary Hypertension.

Tatsuya Akiyama,Taketaro Sadahiro,Yu Yamada,Ryo Fujita,Yuto Abe,Koji Nakano,Seiichiro Honda,Masatsugu Ema,Yoshiaki Kubota,Satoshi Sakai,Nobuyuki Hizawa,Masaki Ieda

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

Flk1 and Flt1 were differentially expressed in pulmonary ECs. Flk1 deficiency and hypoxia jointly dysregulated arteriolar ECs to promote vascular remodeling. Thus, dysfunction of Flk1 ECs may contribute to the pathogenesis of advanced vascular remodeling in pulmonary arterioles.

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关键词

endothelial cells, hypertension, pulmonary, hypoxia, vascular endothelial growth factor A, vascular remodeling

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