A new metabolic pathway for sym-homospermidine synthesis in an extreme thermophile, Thermus thermophilus.
The Journal of general and applied microbiology(2023)
摘要
In an extreme thermophile, Thermus thermophilus, sym-homospermidine is synthesized by the actions of two enzymes. The first enzyme coded by dhs gene (annotated to be deoxyhypusine synthase gene) catalyzes synthesis of an intermediate, supposed to be 1,9-b i s ( g u a n i d i n o )-5-a z a-n o n a n e (=N1, N11-bis(amidino)-sym-homospermidine), from two molecules of agmatine in the presence of NAD. The second enzyme (aminopropylagmatinase) coded by speB gene catalyzes hydrolysis of the intermediate compound to sym-homospermidine releasing two molecules of urea.
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关键词
aminopropylagmatinase,deoxyhypusine,synthase,polyamine metabolism,thermophile,Thermus thermophilus
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