Complex Urban Atmospheres alters Alveolar Stem Cells Niche Properties and drives Lung Fibrosis.

Randa Belgacemi,Bruno Ribeiro Baptista,Grégoire Justeau,Marylène Toigo,Andrew Frauenpreis,Rojda Yilmaz,Audrey Der Vartanian,Mathieu Cazaunau,Edouard Pangui,Antonin Bergé,Aline Gratien, Juan Camilo Macias Rodriguez,Saverio Bellusci,Geneviève Derumeaux,Jorge Boczkowski,Denise Al Alam,Patrice Coll,Sophie Lanone,Laurent Boyer

American journal of physiology. Lung cellular and molecular physiology（2023）

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摘要

Urban atmosphere alters alveolar mesenchymal stem cell niche properties by inducing a lipofibroblast to myofibroblast shift. It also results in alveolar epithelial dysfunction and a fibrotic phenotype.

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关键词

alveolar stem cell niche, complex atmosphere, fibrosis, lung, urban

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