Hydrogen peroxide-induced oxidative damage and protective role of peroxiredoxin 6 protein via EGFR/ERK signaling pathway in RPE cells.

Xiaodong Chen,Radouil Tzekov,Mingyang Su, Yusheng Zhu,Aidong Han,Wensheng Li

Frontiers in aging neuroscience（2023）

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摘要

Our findings indicate that PRDX6 overexpression protects RPE cells from oxidative stress damage caused by decreasing ROS production and partially blocking the inhibition of the EGFR/ERK signaling pathway induced by oxidative stress. Therefore, PRDX6 shows promise as a therapeutic target for the prevention of RPE cell damage caused by oxidative stress associated with retinal diseases.

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关键词

Peroxiredoxin 6, retinal pigment epithelium cell, oxidative stress, epidermal growth factor receptor, extracellular signal-regulated kinase

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