PGD2/PTGDR2 Signal Affects the Viability, Invasion, Apoptosis, and Stemness of Gastric Cancer Stem Cells and Prevents the Progression of Gastric Cancer.

Qiang Zhang,Feifan Wang,Yan Huang, Peiyao Gao,Na Wang, Hengjin Tian, Amin Chen,Yuyun Li,Fengchao Wang

Combinatorial chemistry & high throughput screening（2023）

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摘要

Our data suggest that PGD2 may be an important marker and potential therapeutic target in the clinical management of GC. L-PTGDS/PTGDR2 may be one of the critical targets for GC therapy. The PGD2/PTGDR2 signal affects the viability, invasion, apoptosis, and stemness of GCSCs and prevents the progression of GC.

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