Positive independent association between preoperative endogenous testosterone density and tumor load density in surgical specimen of patients undergoing radical prostatectomy.

Antonio Benito Porcaro,Alberto Bianchi,Sebastian Gallina,Emanuele Serafin,Giovanni Mazzucato,Andrea Panunzio,Alessandro Tafuri,Francesca Montanaro,Giulia Marafioti Patuzzo,Alberto Baielli,Francesco Artoni,Stefano Vidiri,Francesco Cianflone,Damiano D'Aietti,Matteo Brunelli,Salvatore Siracusano,Maria Angela Cerruto,Alessandro Antonelli

Urologia（2023）

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摘要

At diagnosis of PCa, a positive independent association was found between ETD and risk of high TLD. Subjects with increasing ETD levels were more likely to have high TLD, associated with unfavorable pathology features. The positive association between ETD and TLD in the prostate microenvironment might adversely influence PCa's natural history.

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Prostate cancer, radical prostatectomy, endogenous testosterone, percentage of biopsy positive cores density, tumor load

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