Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity.
Bioorganic chemistry(2023)
摘要
Six griseofulvin analogues named penigriseofulvins A - F (1-6), including three undescribed compounds and three undescribed natural products, were isolated from the fungus Penicillium griseofulvum. Their structures and absolute configurations were determined by NMR spectroscopic analyses, HRESIMS, and X-ray diffraction experiments. All compounds were evaluated for their anti-inflammatory activity, of which compounds 1 and 4 showed potential anti-inflammatory effects in RAW264.7 macrophages and ulcerative colitis mice.
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关键词
Penicillium griseofulvum, Griseofulvin, Anti-inflammatory activity, Inflammatory bowel disease, Ulcerative colitis
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