Analysis 33 patients of non-DS-AMKL with or without acquired trisomy 21 from multiple centers and compared to 118 AML patients.

Wenzhi Zhang,Jianxin Dun,Hui Li, Jingzhen Liu,Hongbo Chen,Hui Yu,Jiawei Xu,Fen Zhou,Yining Qiu,Jinjin Hao,Qun Hu,Xiaoyan Wu

Hematology (Amsterdam, Netherlands)（2023）

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摘要

Due to high heterogeneity, high misdiagnosis rate, and myelofibrosis, parts of AMKL may take a long time to be diagnosed, requiring repeated bone marrow punctures. Complex karyotype was common in AMKL. +21 may not be a promising indicator of a poor prognosis.

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关键词

Acute megakaryocytic leukemia, acquired trisomy 21, cytogenetics, prognostic factors, children, >

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