Exploring the role of ex vivo metabolism on blood and plasma measurements of oxytocin among women in the third stage of labour: a post-hoc study.

Victoria L Oliver,Sarah Siederer,Anthony Cahn,Katarzyna Gajewska-Knapik,Rachel A Gibson,Cleo Goodall,Carl Kirkpatrick, Jack Murray,Tri-Hung Nguyen,Ian Schneider,Pete Lambert,Michelle P McIntosh,Simon Parry

British journal of clinical pharmacology（2023）

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摘要

Collection of blood from late-stage pregnant women into tubes containing EDTA inhibits oxytocinase effectively stabilises oxytocin, suggesting low concentrations of oxytocin after dose administration reflect rapid in vivo metabolism.

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关键词

obstetric haemorrhage, oxytocin, oxytocinase

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