Western Diet Induced Transcriptional Changes in Anastomotic Tissue is Associated with Early Local Recurrence in a Mouse Model of Colorectal Surgery.

Janani Vigneswaran,Robert C Keskey,Ryan B Morgan,John C Alverdy,Lindsay Alpert,Eugene Chang,Ralph Weichselbaum,Olga Zaborina,Benjamin D Shogan

Annals of surgery（2023）

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摘要

A WD promotes cancer cells to permeate a healing anastomosis and migrate into anastomotic and lymphatic tissue forming viable tumor nodules. These data offer a novel recurrence pathogenesis by which the intestinal microenvironment promotes a CRC local-regional recurrence.

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