Inhibition of Pro-Inflammatory Microglia with Minocycline Improves Cognitive and Sleep-Wake Dysfunction Under Respiratory Stress in a Sporadic Model for Alzheimer's Disease.

Mariane C Vicente, Julia L Paneghini, Angelita M Stabile, Mateus Amorim, Conceição E Anibal Silva,Luis Gustavo A Patrone,Thiago M Cunha,Kênia C Bícego,Maria C Almeida,Daniel C Carrettiero,Luciane H Gargaglioni

Journal of Alzheimer's disease : JAD（2023）

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摘要

Our findings suggest that minocycline effectively reduces microglial recruitment and the inflammatory morphological profile in the LC, while it recovers cognitive performance and restores the sleep-wake pattern impaired by STZ.

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关键词

microglia,alzheimers,minocycline,respiratory stress,pro-inflammatory,sleep-wake

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