Immunogenicity of Bacillus Calmette-Guérin in pigs: potential as a translational model of non-specific effects of BCG.

Kristoffer Jarlov Jensen,Mette Sif Hansen,Kerstin Skovgaard,Erik Svensson,Lars Erik Larsen,Peter M H Heegaard,Christine Stabell Benn,Gregers Jungersen

Frontiers in immunology（2023）

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摘要

BCG was safe in pigs, inducing specific immunological responses, but our model did not corroborate the innate immunological responsiveness to BCG seen in humans. The dose of BCG or the bacterial and viral challenges may have been sub-optimal. Even so, the acute phase protein response to influenza infection was significantly reduced in BCG-vaccinated animals.

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non-specific effects, heterologous immunity, pigs, BCG, Actinobacillus pleuropneumoniae, influenza virus

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