Early protective effect of a ("pan") coronavirus vaccine (PanCoVac) in Roborovski dwarf hamsters after single-low dose intranasal administration.

Mohammed O Abdelaziz,Martin J Raftery, Julian Weihs, Olivia Bielawski, Richard Edel,Julia Köppke,Daria Vladimirova,Julia M Adler,Theresa Firsching, Anne Voß,Achim D Gruber, Luca V Hummel, Ivan Fernandez Munoz, Francesca Müller-Marquardt,Gerald Willimsky, Nooran S Elleboudy,Jakob Trimpert,Günther Schönrich

Frontiers in immunology（2023）

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摘要

PanCoVac, a multi-epitope vaccine covering conserved T cell epitopes from all structural proteins of coronaviruses, might protect from severe disease caused by SARS-CoV-2 variants and future pathogenic coronaviruses. The use of (HLA-) humanized animal models will allow for further efficacy studies of PanCoVac-based vaccines .

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关键词

coronavirus vaccine,roborovski dwarf hamsters,pancovac,early protective effect,single-low

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