TRIM3 attenuates cytokine storm caused by Dabie bandavirus via promoting Toll-like receptor 3 degradation.

Ke Jin,Yan Dai,Ke Ouyang,Huaying Huang,Zhengyi Jiang,Zhan Yang,Tingting Zhou,Hong Lin,Chunhui Wang,Chunyan Wang,Xuewei Sun,Dafeng Lu,Xiaoguang Liu,Nannan Hu,Chuanlong Zhu,Jin Zhu,Jun Li

Frontiers in microbiology（2023）

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摘要

TRIM3 can inhibit the production of cytokines by regulating the degradation of TLR3 through K48-linked ubiquitination, which can be a therapeutic target for improving the prognosis of SFTS.

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关键词

severe fever with thrombocytopenia syndrome, Dabie bandavirus, TRIM3, Toll-like receptor 3, cytokine storm

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