Development of a novel humanized mouse model to study bronchopulmonary dysplasia.

Frontiers in pediatrics(2023)

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摘要
Despite the inherent absence of macrophages in early stages of lung development, immunodeficient MISTRG mice revealed changes in alveolar and microvascular development induced by human monocytes. MISTRG mice exposed to neonatal hyperoxia may serve as a novel model to study isolated effects of human monocytes on alveolar and pulmonary vascular development.
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关键词
bronchopulmonary dysplasia,mouse model
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