Clinical features and prognostic significance of DNMT3A, FLT3, and NPM1 mutations in de novo acute myeloid leukemia patients.

Meiyu Chen,Zhao Zeng,Xuewei Li,Wei Qin,Xiaohui Cai,Suning Chen,Xuzhang Lu

International journal of laboratory hematology（2023）

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摘要

We comprehensively evaluated the clinical and genetic characteristics, and expression profiles of AML patients with common mutations, and found that AML patients with triple mutations might be a distinct AML subtype, which should be redefined.

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关键词

acute myeloid leukemia, DNMT3A, FLT3, genetic mutations, NPM1, prognosis

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