Huangkui capsule attenuates diabetic kidney disease through the induction of mitophagy mediated by STING1/PINK1 signaling in tubular cells.

Zhen Zhu,Guangxin Luan,Shiqiao Peng,Yunyun Fang, Qiongqiong Fang,Shuang Shen,Kaiyue Wu,Shengnan Qian,Weiping Jia,Jianping Ye,Li Wei

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

Our results suggest that HKC ameliorates renal tubulopathy in DKD and induces mitophagy partly through the up-regulation of the STING1/PINK1 pathway. These findings may provide an innovative therapeutic basis for DKD treatment.

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关键词

Huangkui capsule, Diabetic kidney disease, Mitophagy, Mitochondrial homeostasis, STING1/PINK1 signal

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