Netrank: network-based approach for biomarker discovery.
BMC bioinformatics(2023)
摘要
In this paper we provide a fast and efficient implementation of NetRank, with a case study from The Cancer Genome Atlas, to assess the performance. We incorporated complete functionality for pre and post-processing for RNA-seq gene expression data with functions for building protein-protein interaction networks. The source code of NetRank is freely available (at github.com/Alfatlawi/Omics-NetRank) with an installable R library. We also deliver a comprehensive practical user manual with examples and data attached to this paper.
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关键词
Biomarker, Cancer, Protein networks, RNA, Gene expression, R package
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