PI3K-CCL2-CCR2-MDSCs axis: A potential pathway for tumor Clostridia-promoted CD 8 + T lymphocyte infiltration in bile tract cancers.

Wen-Jie Ma,Zheng-Hua Li,Zhen-Ru Wu,Fei Liu,Jun-Ke Wang,Yu-Jun Shi,Yan-Wen Jin,Fu-Yu Li

Neoplasia (New York, N.Y.)（2023）

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摘要

The tumor microbiome is related to CD8 T lymphocyte infiltration in patients with resected BTCs. The relationship between tumor Clostridia and high infiltration of CD8 T lymphocytes might reflect decreased recruitment of myeloid-derived suppressor cells via the PI3K-CCL2-CCR2 axis.

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关键词

Bile tract cancers,Tumor microbiome,CD8+ T lymphocyte,Myeloid-derived suppressor cell,Phosphatidylinositol 3-kinase activity

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