Zhiqiao Gancao Decoction Ameliorates Hyperalgesia in Lumbar Disc Herniation via the CCL2/CCR2 Signaling Pathway.

Zeling Huang,Binjie Lu,Xianda Zhang,Jiangping Wang,Xuefeng Cai,Yujiang Liu, Jianxiong Mo,Yuwei Li,Bo Xu,Xiaofeng Shen

Drug Design, Development and Therapy（2023）

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摘要

The CCL2/CCR2 pathway was activated in the intervertebral disc and DRG of LDH rats. This was accompanied by upregulation of ASIC3 expression, increased excitability of DRGn, and the occurrence of hyperalgesia. ZQGCD improves hyperalgesia in LDH rats by inhibiting the CCL2/CCR2 pathway and downregulating ASIC3 expression.

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关键词

lumbar disc herniation,dorsal root ganglion neurons,hyperalgesia,traditional chinese medicine,molecular docking.

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