The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(-) and in an Increased Percentage among HPV(+) Norwegian HNSCC Patients.

Svein Erik Moe,Fredrik A Erland,Siren Fromreide,Stein Lybak,Marianne Brydoy,Harsh N Dongre,Sophia M Dhayalan,Daniela-Elena Costea,Olav K Vintermyr,Hans Jørgen Aarstad

Biomedicines（2023）

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摘要

BACKGROUND:Somatic TP53OBJECTIVE:To study TP53METHODS:Using a custom-made next-generation sequencing (NGS) panel on formalin-fixed, paraffin-embedded tumor tissue, we analyzed somatic TP53TP53RESULTS:Only 2 of 44 patients with HPV-positive (HPV(+)) HNSCC had a TP53pTP53TP53TP53TP53pTP53pTP53pCONCLUSIONS:Our observations show that TP53TP53

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关键词

increased tp53 somatic mutations,tp53 codon,norwegian hnscc patients,hpv−,arginine polymorphism

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