The Tam Formula: A Pilot Study For A New Treatment For Melasma

Background Melasma is a common hyperpigmentation disorder with numerous, but often unsatisfactory treatment options.Aims A pilot study to evaluate the efficacy and safety of a novel topical combination of 12% hydroquinone, 6% kojic acid, and 5% vitamin C cream for melasma.Patients and Methods A pilot study of 6 women with melasma was conducted at an academic dermatology department and a private dermatology practice to evaluate the efficacy of a topical combination of 12% hydroquinone, 6% kojic acid, and 5% vitamin C cream, entitled the "Tam Formula." Two blinded evaluators calculated Melasma Area and Severity Index (MASI) Scores before and after treatment to evaluate change from baseline, and statistical analysis was performed.Results Treatment with this combination topical cream resulted in an average 63.77 +/- 22.10 percent reduction in MASI scores.Conclusions While there is a need for further investigation, this pilot study indicates the Tam Formula may provide an alternative treatment option for melasma.