Upregulation of circ_0080968 in diabetic foot ulcer inhibits wound healing via repressing the migration and promoting proliferation of keratinocytes

Zhonghua Fu,Zhengying Jiang,Xincheng Liao,Mingzhuo Liu,Guanghua Guo,Xin Wang, Guangping Yang, Zhiyu Zhou, Long Hu,Zhenfang Xiong

Gene（2023）

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摘要

•CircRNA-080968 is upregulated in diabetic foot ulcer (DFU).•CircRNA-080968 represses migration and promotes proliferation of keratinocytes.•MiR-326 and miR-766-3p interact with circRNA-080968.•CircRNA-080968 induces the degradation of miR-326 and miR-766-3p.•MiR-326 and miR-766-3p target genes regulating cell adhesion and proliferation.

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关键词

Diabetic foot ulcer,Circular RNA,Mirna,Keratinocyte

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