Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy

Journal of advanced research(2023)

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摘要
•CircRNA hsa_circ_0001402 inhibits VSMC proliferation and migration, while activating VSMC autophagy, thereby alleviating neointimal hyperplasia.•MiR-183-5p decreases FKBPL levels by targeting the coding sequence of FKBPL, promoting VSMC proliferation and migration, thereby exacerbating neointimal hyperplasia.•MiR-183-5p reduces BECN1 levels by targeting the 3′-untranslated region of BECN1, inhibiting VSMC autophagy, thus exacerbating neointimal hyperplasia.•Hsa_circ_0001402 acts as a sponge for miR-183-5p.
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关键词
hsa_circ_0001402,miR-183-5p,Vascular smooth muscle cell,Proliferation,Migration,Autophagy,Neointima hyperplasia
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