IPO11 Regulates the Nuclear Import of BZW1/2 and Is Necessary for AML Cells and Stem Cells

Boaz Nachmias,Veronique Voisin,Geethu Emily Thomas,Dilshad H. Khan,Rose Hurren,Aaron Botham, Xiaoming Wang,Neil Maclean,Ayesh K Seneviratne,Changjiang Xu,Jonathan St-Germain,Andrea Arruda,Elias Orouji,Liran I. Shlush,Mark D. Minden,Brian Raught,Gary D Bader,Aaron D Schimmer

Blood（2020）

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摘要

While most patients with acute myeloid leukemia (AML) achieve remission with initial therapy, the majority relapse leading to poor overall survival. Relapse is frequently driven by a rare subset of leukemic stem cells (LSC). Understanding biological mechanisms that maintain LSCs will help identify new therapeutic strategies for this disease.

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