Pomegranate peel-derived punicalagin: Ultrasonic-assisted extraction, purification, and its α-glucosidase inhibitory mechanism

Yi Liu,Kin Weng Kong,Ding-Tao Wu,Hong-Yan Liu,Hua-Bin Li,Jia-Rong Zhang,Ren-You Gan

Food Chemistry（2022）

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摘要

•The main polyphenols of pomegranate peels were identified by LC-MS/MS.•Punicalagin from pomegranate peels was extracted under optimal UAE.•Punicalagin was purified by D101 macroporous resin and prep-HPLC.•α-Glucosidase inhibitory mechanism of punicalagin was studied.•Molecular docking indicated the interactions between punicalagin and α-glucosidase.

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关键词

Polyphenols,Ultrasonic-assisted extraction,LC-MS/MS,α-Glucosidase,Inhibition kinetic,Molecular docking

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