Impact of Sickle Cell Trait on Morbidity and Mortality from Sars-Cov-2 Infection

Introduction: The high morbidity and mortality of SARS-CoV-2 in Blacks or African American in the United States is well established. Individuals with sickle cell trait (SCT), who are mostly Black or African American, have adverse health outcomes in situations of increased physiologic stress. The novel corona virus SARS-CoV-2 causes a severe multi-systemic viral infection that induces intense inflammation and metabolic derangements that can exacerbate RBC sickling and organ damage. The purpose of this study is to evaluate the impact of SCT status on the outcome of patients hospitalized for SARS-CoV-2.