Early phase clinical trials in oncology: Realising the potential of seamless designs

Thomas Jaki, Abigail Burdon, Xijin Chen,Pavel Mozgunov,Haiyan Zheng,Richard Baird

European Journal of Cancer（2023）

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摘要

•Modern methods for dose-finding have the potential to improve dose selection.•Seamless Phase I/II trials are efficient in determining a safe and active dose.•Small changes to current approaches can improve the efficiency of dose-finding trials.

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关键词

Efficient trials,Model-based designs,Dose-determination

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