Fine particulate matter-induced lung inflammation is mediated by pyroptosis in mice
Ecotoxicology and Environmental Safety(2021)
摘要
•PM2.5 exposure caused lung injury and inflammation in mice.•Inhibition of NALRP3/Caspase-1 signaling pathway can amelioration PM2.5-induced lung toxicity.•PM2.5 exposure induced lung toxicity is related to NALRP3 inflammasome mediated macrophage pyroptosis.
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关键词
PM2.5,Lung toxicity,Lung inflammation,NLRP3,Pyroptosis
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