Catalytic nanovaccine for cancer immunotherapy: A NADPH oxidase-inspired Fe-polyphenol network nanovaccine for enhanced antigen cross-presentation

Gaowei Chong,Runping Su,Jingjing Gu,Yushan Yang,Tingting Zhang,Jie Zang,Yuge Zhao,Xiao Zheng,Ying Liu,Shuangrong Ruan,Ruiqing He,Weimin Yin,Yan Li,Haiqing Dong,Yongyong Li

Chemical Engineering Journal（2022）

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摘要

•A catalytic OVA@FG nanovaccine provides a new perspective for vaccine design.•“Fe-GA catalytic unit” mimicked the ROS transfer process of NOX2 in organisms.•The fusiform-like OVA@FG exerted effective antigen cross-presentation in vivo.•OVA@FG promoted potent antitumor immunotherapy.

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关键词

Catalytic nanovaccines,NOX2,Fe-polyphenol networks,ROS,Antigen cross-presentation

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