Rapid extraction of osimertinib and its active metabolite in urine by miniaturized centrifugal spin-column extraction using ionic liquid hybrid hierarchical porous adsorbent

Yehong Han,Mingyu Wang,Chunliu Yang,Zihui Zhao,Yanan Yuan,Hongyuan Yan

Journal of Chromatography A（2023）

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摘要

•A hierarchical porous structure and fast mass transfer IL-HHPM was designed.•IL as monomer increase the specific surface area and multiple functional groups.•A new rapid and miniaturized IL-HHPM-MCSCE method was first developed.•A new HPLC method for detection of OSIM and AZ5104 in urine was proposed.

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关键词

osimertinib,rapid extraction,ionic liquid,active metabolite,spin-column

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