Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production.

Sangshan Tian,Devendra Paudel,Fuhua Hao,Rabin Neupane,Rita Castro,Andrew D Patterson,Amit K Tiwari,K Sandeep Prabhu,Vishal Singh

Cancer reports (Hoboken, N.J.)（2023）

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摘要

Our study uncovers that supplementation of diet with refined inulin induces abnormal succinate accumulation in the intestinal lumen, which in part contributes to promoting colon inflammation and tumorigenesis.

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关键词

colon cancer,gut microbiota,inflammatory bowel disease,microbial metabolism,nutrition,prebiotic fiber

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