B7-H3 confers stemness characteristics to gastric cancer cells by promoting glutathione metabolism through AKT/pAKT/Nrf2 pathway.

Lu Xia,Yuqi Chen,Juntao Li,Jiayu Wang,Kanger Shen,Anjing Zhao,Haiyan Jin,Guangbo Zhang,Qinhua Xi,Suhua Xia,Tongguo Shi,Rui Li

Chinese medical journal（2023）

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摘要

B7-H3 has a regulatory effect on GC stemness and the regulatory effect is achieved through the AKT/Nrf2/GSH pathway. Inhibiting B7-H3 expression may be a new therapeutic strategy against GC.

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