Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank.

Lewis Forsyth,Alisha Aman,Breda Cullen,Nicholas Graham,Donald M Lyall,Laura M Lyall,Jill P Pell,Joey Ward,Daniel J Smith,Rona J Strawbridge

Journal of affective disorders（2023）

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摘要

Genetic variation in the DCC locus had distinct effects on BMI, smoking and mood traits, and therefore is unlikely to contribute to shared mechanisms underpinning mental and cardiometabolic traits.

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关键词

Genetic variation,DCC,Anhedonia,Neuroticism,Mood instability,Body-mass index,Smoking

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